Academic presentation

Society for Cutaneous Ultrastructure Research

Suppressive effect of Arnica montana on IL-6 production

Akihiro Aioi
SPTM R&D Australia、School of Med, University of Queensland
Roy Kimble, James McMillan
School of Med, University of Queensland

[Abstract]
Interleukin (IL)-6 is a well-known participant in cutaneous inflammatory reactions. Previous cytokine array studies have shown a differential expression of specific cytokines in tissue cultured (myo-)fibroblast populations derived from steady state control dermal tissue (NHF), TGF-b1-treated NHF and hypertrophic scar derived fibroblasts (HSF). Interleukin-6 (IL-6) was one such cytokine identified as upregulated in TGF-b1-treated NHF or HSF fibroblast cultures compared to steady state control dermal fibroblasts. We have examined the suppressive effect of over 200 plant extracts on IL-6, which is a well-known participant in cutaneous inflammatory reactions. IL-6 production from RAW264.7 cells stimulated with lipopolysaccharide (LPS) was suppressed by Arnica extract in a dose-dependent manner, as well as prostaglandin E2 and endothelin-1. According to a recent study (Verma, N. et al., Mol. Cell Biochem. 336(1-2), 127 (2010)), LPS-induced TNF-a production from RAW264.7 a murine macrophage cell line was attenuated, concomitant with inhibition of nuclear translocation of NFkB. Conversely, previous studies demonstrated that TGF-b1 up-regulates collagen synthesis and IL-6 production in dermal fibroblasts via Smad signal transduction. To evaluate the effect of Arnica extract on IL-6 production stimulated by TGF-b1 we used normal human dermal fibroblast (NHDF) and hypertrophic scar fibroblast (HSF) that spontaneously produce TGF-b1. Arnica extract suppressed IL-6 production from both TGF-b1-stimulated NHDF and HSF. Taken together, these results suggest that Arnica extract down-regulates IL-6 production via NFkB and Smad pathways and that Arnica extract is a candidate treatment for skin diseases in which IL-6 plays pivotal roles.

Academic presentation

  1. The 70th Japanese Biochemical Society

    ATR is involved in ouble stranded DNA-induced cellular senescence

  2. The 24th Japanese Society of Anti-aging Medicine

    Is NUMB a candidate for a novel cellular senescence marker

  3. The 15th Conference of the Tokyo Society of Physical Education,Health and Sport Science

    Does Electrical Stimulation of Skeletal Muscle with High Frequency Modulated Multiple Complex Waves Improve Skeletal Muscle and Cognitive Functions in Middle Aged and Elderly People?

  4. The 36th Meeting of the Japanese Association of Health Psychology

    『Study on the mind and skin 』2

  5. The 41th Annual Meeting of the Japanese Society of Aesthetic Dermatology

    Effect of placenta extracts and fractions(2)

  6. 1st International Societies for Investigative Dermatology

    The transfection of double-stranded DNA induces cell senescence in cultured human keratinocytes

  7. Journal of Cosmetics, Dermatological Sciences and Applications Vol.12 No.1

    Baicalein and Salvia officinalis extract upregulate transglutaminase

  8. Trends in Immunotherapy

    Inflammaging in skin and intrinsic underlying factors

  9. Journal of Cosmetics, Dermatological Sciences and Applications Vol. 11 No. 2

    Porcine Placenta Extract Reduced Wrinkle Formation by Potentiating Epidermal Hydration

  10. The 33nd Meeting of the Japanese Association of Health Psychology

    Study of『The heart and the skin』part1 ~ an influence of the heart on the skin condition ~

  11. The International Federation of Societies of Cosmetic Chemists (IFSCC)

    Psychological stress is an initiator of skin problems due to dysfunction of the epidermal barrier caused by abnormal differentiation. - A Gingko leaf extract is an excellent candidate for dealing with psychological stress

  12. Trends in Immunotherapy Vol.2 No.4

    Peroxisome proliferator-activated receptors (PPARs) activation as therapeutic targets in skin inflammation

  13. 138th Annual Meeting of the Pharmaceutical Society of Japan

    Study of polymethoxylated flavone on antioxidant mechanism in human keratinocyte.

  14. Trends in Immunotherapy Vol.1 No.3

    Sirtuins in wound healing.

  15. Glycative Stress Research

    Reduction effect of oxidized protein hydrolase (OPH) on advanced glycation end products and OPH-like activity in human stratum corneum.

  16. The 35th Annual Meeting of the Japanese Society of Aesthetic Dermatology

    Effect of a gel formula containing porcine placenta extract and its mechanism.

  17. The January number of the “FRAGRANCE JOURNAL”

    Effect of OPH (oxidized protein hydrolase) activity on glycation stress in skin.

  18. The 41th Annual Meeting of the Japanese Society for Investigative Dermatology

    Roles of intracellular carbonylated protein and oxidized protein hydrolase on reconstruction of basement membrane.

  19. The 16th Scientific Meeting of the Japanese Society of Anti-Aging Medicine

    Search of an activation ingredient of OPH in horny layer.

  20. The 41th Convention of the Japanese Cosmetic Science Society

    Relationship between Intracellular Carbonylated Protein and Oxidized Protein Hydrolase.

  21. The 16th Annual Meeting of Society for Photoaging Research

    Development of composite powder focus on near-infrared ray and its application in cosmetics.

  22. The 15th Scientific Meeting of the Japanese Society of Anti-Aging Medicine

    Search of an activation ingredient of OPH in horny layer.

  23. The 12th Asian Society of Cosmetic Scientist

    Anti-oxidant Effect of Sapindaceae Dodonaea

  24. The 12th Asian Society of Cosmetic Scientist

    New approach against photoaging

  25. The 14th Scientific Meeting of the Japanese Society of Anti-Aging Medicine

    Study of OPH activity in horny layer.

  26. 5th International Conference on Natural Products for Health and Beauty

    Suppression of IL-6 production by Euphorbia sarcostemmoides extract

  27. ”Journal of Japanese Cosmetic Science Society” Thesis Submission

    Suppressive effect of Arnica montana extract on mediators

  28. The 36th Annual Meeting of the Japanese Society for Investigative Dermatology

    The role of IL-6 in α-SMA expression in myofibroblast

  29. The 94th Annual Meeting of Japanese Society for Bacteriology

    Analysis of skin microbiota under various skin conditions

  30. The 36th Annual Meeting of Japanese Cosmetic Science Society

    Effects of Arnica montana extract on mediator productions

  31. Society for Cutaneous Ultrastructure Research

    Suppressive effect of Arnica montana on IL-6 production

  32. “The Allergy in Practice” Thesis Submission

    The effect of Poria Sclerotium on ceramide synthesis

  33. “COSMETIC STAGE” Contribution

    Troubleshootings about in-vivo Evaluation of Skin Care Cosmetics.

  34. 10th International Congress of Physiological Anthropology

    Influence of natural solar exposure for 3 hours to immunological parameters and heart rate variability in humans

  35. The 35th Annual Meeting of Japanese Cosmetic Science Society

    Poria Sclerotium Stimulatory Effect of Ceramide Synthesis

  36. The 34th Annual Meeting of the Japanese Society for Investigative Dermatology

    Correlation between measure of pigmentation and water content in epidermis

  37. 31st Japanese Society for Photomedicine and Photobiology

    Influence of natural solar exposure for 3 hours on immunological parameters and mental work performance in humans.

  38. “SKIN RESEARCH” Thesis Submission

    Assessment of the Therapeutic Effect of Hydroquinone Stabilized in Cream

This site is protected by reCAPTCHA and is subject to Google's privacy policy.
PAGE TOP